Association of VDR BsmI polymorphism and vitamin D status with osteoarthritis susceptibility

The findings indicate that the VDR BsmI polymorphism is associated with knee osteoarthritis in the Kurdish population, whereas FokI, ApaI, and TaqI loci were non-polymorphic. These results highlight population-specific genetic variation within the VDR gene and underscore the need for larger studies incorporating functional validation to clarify the biological relevance of BsmI variation in osteoarthritis.

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Publication Details

Journal
BMC Medical Genomics
Published
2026-03-02
DOI
https://doi.org/10.1186/s12920-026-02339-0
Primary Topic
Vitamin D Research Studies
Type
article
Field-Weighted Citation Impact
0.00
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Association of VDR BsmI polymorphism and vitamin D status with osteoarthritis susceptibility

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BMC Medical Genomics
Vitamin D Research Studies
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Association of VDR BsmI polymorphism and vitamin D status with osteoarthritis susceptibility

Shahab H. Agha, Treska S Hassan, Raya Kh. Yashooa, Mukhlis Aali, Suhad A. Mustafa, Rebar Nadhem A. Daham, Haween T. Hassan, Shawnim M. Maaruf, Azhin D. Aziz
article en

Abstract

The findings indicate that the VDR BsmI polymorphism is associated with knee osteoarthritis in the Kurdish population, whereas FokI, ApaI, and TaqI loci were non-polymorphic. These results highlight population-specific genetic variation within the VDR gene and underscore the need for larger studies incorporating functional validation to clarify the biological relevance of BsmI variation in osteoarthritis.

BMC Medical Genomics
University of Mosul (IQ), Hawler Medical University (IQ), Kurdistan Regional Government (IQ), Karolinska Institutet (SE), University of Kurdistan Hewler (IQ), University of Al-Qadisiyah (IQ), Salahaddin University-Erbil (IQ)
Openalex Percentile: Top 38%
Vitamin D Research Studies
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