Maternal hyperuricemia and adverse neonatal outcomes in normotensive pregnancies: Evidence from a prospective cohort study in Eastern Uganda
Adverse neonatal outcomes occurred in 37.5% of participants. Hyperuricemic women had significantly higher composite risk (62.5% vs. 12.5%; aRR = 4.32, 95% CI 2.92-6.39). Hyperuricemia independently predicted preterm birth (aRR = 3.63, 95% CI 1.70-7.72), SGA (aRR = 2.80, 95% CI 1.61-4.86), and stillbirth (aRR = 5.00, 95% CI 1.47-16.99). Maternal age ≥ 40 years, low education, < 4 antenatal visits, previous preterm birth, previous stillbirth, and obesity were also associated with adverse outcomes. Conclusions. Maternal hyperuricemia is a strong predictor of preterm birth, SGA, and stillbirth. Routine SUA screening during antenatal care, combined with closer monitoring of high-risk women, could help improve neonatal outcomes.
Authors
- Maxwell Okello
- Theoneste Hakizimana (ORCID: https://orcid.org/0000-0002-1294-2981)
- Marie Pascaline Sabine Ishimwe
- Musa Kasujja (ORCID: https://orcid.org/0009-0000-1861-8181)
- Geoffrey Okot
- Ibrahim Bwaga
- Ahmed Kiswezi Kazigo
- Theodore Nteziyaremye
- Mohamud Mohamed Sadia
- Ramlo Abdi Ali
- Hussein Mire Hamdi
- Hassan Abdullahi Hafsa
- Sawda Abdikarim Sheikh Isse
- Adam Abdrahim Suliman Ebaid
Institutions
- Kampala International University (UG)
- University of Kigali (RW)
- University of Rwanda (RW)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1371/journal.pone.0342913
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00