The genetic architecture of postoperative delirium after major surgery and its relationship with nonpostoperative neurocognitive conditions: A genome-wide association study
We identified genetic variants associated with increased risk of postoperative delirium. We also found evidence of shared genetic liability with Alzheimer's disease via APOE, complementing recent large-scale studies in all-cause delirium. If validated, the findings have potential clinical applications, including preoperative risk stratification and early identification of pre-clinical Alzheimer's disease risk.
Authors
- Paul Yousefi (ORCID: https://orcid.org/0000-0003-3284-3240)
- Ben Gibbison
- Golam M. Khandaker
- Tom R. Gaunt
- Richard A. Armstrong
Institutions
- Avon and Wiltshire Mental Health Partnership NHS Trust (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- University of Bristol (GB)
- NIHR Bristol Biomedical Research Centre (GB)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1371/journal.pmed.1004963
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- UK Research and Innovation
- National Institute for Health and Care Research
- Department of Health and Social Care
- University of Bristol
- Medical Research Council