Single cell and multi-omics analysis reveal senescence-related molecular subtypes and a prognostic signature in clear cell renal cell carcinoma
In this study, we uncovered the diverse patterns of cellular senescence within ccRCC and developed a senescence-derived risk score that demonstrated strong prognostic value. Moreover, ALDH18A1 was identified as a promising biomarker for prognosis and a potential therapeutic target in ccRCC.
Authors
- Yingqing Liu
- Lingsong Tao (ORCID: https://orcid.org/0000-0002-3254-506X)
- Yuting Zhao (ORCID: https://orcid.org/0000-0001-6178-0547)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-5246-5497)
- Z K Yu
- Wenchuan Shao
- Weiyu Kong
- Chaozhao Liang
- Heqian Liu
- Mingcong Zhang
- Zehong Gao
Institutions
- Anhui Medical University (CN)
- Washington University in St. Louis (US)
- Lianyungang Oriental Hospital (CN)
- Wuhu Fourth People Hospital (CN)
- Wuhu No 1 People's Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1007/s12672-026-04674-1
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00