Cross-Modality Whole-Heart MRI Reconstruction with Deep Motion Correction and Super-Resolution

Magnetic resonance imaging (MRI) inherently suffers from motion artifacts and inter-slice misalignment, primarily due to sequential slice acquisition and the prolonged scanning time required for dynamic cardiac motion. These acquisition-induced inconsistencies often lead to anatomically implausible representations of cardiac structures, impairing subsequent clinical analyses such as 3D reconstruction and regional functional assessment. On the other hand, acquiring high-resolution MRI demands extended scan durations that increase patient burden and potential health risks. To address this challenge, we propose a deep motion correction and super-resolution whole-heart reconstruction (DeepWHR) framework. It learns cardiac structure prior knowledge from computed tomography (CT) data, and transfers it to reconstruct cardiac structure from conventional misaligned and large slice thickness MRI images. Specifically, DeepWHR utilizes CT anatomy data to train a deep motion correction model that enables the network to capture structurally coherent and anatomically consistent representations, while MRI Finetune preserves modality-specific spatial characteristics, ensuring that the reconstructed results retain the intrinsic MRI data distribution. Furthermore, DeepWHR introduced an implicit neural representation module, which models continuous spatial fields, enabling multi-scale super-resolution structure reconstruction. Experiments on the CARE2024 WHS dataset validate that our method not only restores the spatial coherence of MRI-derived anatomical structures but also generates high-fidelity label representations suitable for downstream cardiac applications. This study demonstrates that DeepWHR transforms sparse, misaligned 2D label stacks into anatomically coherent, high-resolution 3D models, enhancing their reliability for clinical applications.