Antibodies Against Cytomegalovirus Infection in Pregnancy with Recurrent Miscarriage

Background and objectives: Recurrent pregnancy loss leads to serious obstetrical and psychosocial consequences specifically if causes are unknown. The aim of this study is to evaluate the role of cytomegalovirus infection in women with recurrent pregnancy loss. Methods: This is a case-control study implemented in outpatient's clinic of Maternity hospital in Erbil city over duration of one year from 1st of June, 2022 to 31st of May, 2023 included 100 women with miscarriages recurrences and 100 women without history of miscarriage. A sample of 5 ml blood was drawn from selected women and sent for investigation. Serologically, cytomegalovirus infection was confirmed through recording cytomegalovirus immunoglobulin-G and immunoglobulin-M anti-bodies detection in private laboratory. Results: The age, body mass index, educational level, occupation, residence and parity history of study participants were not statistically different between study groups (p>0.05). The consanguinity was statistically related to controls (40%) and the positive family history of repeated pregnancy loss was statistically related to women with repeated pregnancy loss (12%) (p?0.05). Cytomegalovirus immunoglobulin M seropositivity was not statistically different between study groups (2% versus 2%) (p>0.05), however, cytomegalovirus immunoglobulin G seropositivity was prevalent in women with recurrent pregnancy loss (100%) (p=0.04). Conclusions: The cytomegalovirus infection is a risk factor for miscarriages recurrence.