APP Deficiency Ameliorates FAD Presenilin 1 F105C and A246E Mutations-induced Mitochondrial Dysfunction in Human Cortical Neurons
These findings provide critical insights into the bridging role of APP in FAD PS1 mutant-mediated mitochondrial dysfunction, advancing our understanding of the cellular mechanisms underlying AD.
Authors
- Daijiao Tang
- Ming Chen (ORCID: https://orcid.org/0000-0003-3953-2904)
- Jing-Fang Luo (ORCID: https://orcid.org/0000-0002-3949-2271)
- Su-Chun Zhang
- Fang Yuan
- Yu-Hsin Yen
- Huanxing Su
- Phil-Jun Kang
- Cheong-Meng Chong
Institutions
- University of Macau (MO)
- Discovery Institute (US)
- Duke-NUS Medical School (SG)
Publication Details
- Journal
- International Journal of Biological Sciences
- Published
- 2026-02-18
- DOI
- https://doi.org/10.7150/ijbs.120062
- Primary Topic
- Hereditary Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Emory University
- Ministry of Education, Science and Technology
- Ministry of Education, India
- Universidade de Macau
- Fundo para o Desenvolvimento das Ciências e da Tecnologia