Phase II study of maintenance trifluridine/tipiracil (TAS-102) plus bevacizumab after induction chemotherapy in metastatic colorectal cancer
This strategy of switching to first-line maintenance therapy with TAS+Bev demonstrated promising efficacy and safety. This strategy effectively avoided cumulative neurotoxicity, preserved quality of life and enabled reintroduction of oxaliplatin, suggesting it may represent a promising alternative strategy for patients ineligible for prolonged oxaliplatin-based treatment. Overall survival analysis is currently ongoing. [UMIN Trial ID: UMIN000031317].
Authors
- Yujiro Nishizawa (ORCID: https://orcid.org/0000-0002-9636-4882)
- Yoshinori Kagawa (ORCID: https://orcid.org/0000-0001-6876-4507)
- Tsukasa Tanida
- Shinji Tokuyama
- Satoshi Sugimoto (ORCID: https://orcid.org/0000-0003-0401-0030)
- Hiroshi Tamagawa
- Naohiro Nishida (ORCID: https://orcid.org/0000-0003-3216-8513)
- Masayuki Hiraki (ORCID: https://orcid.org/0000-0001-6445-7390)
- Takayuki Ogino (ORCID: https://orcid.org/0000-0001-5435-4144)
- Hidetoshi Eguchi (ORCID: https://orcid.org/0000-0002-2318-1129)
- Hidekazu Takahashi (ORCID: https://orcid.org/0000-0003-0779-407X)
- T. Kudo
- Terukazu Yoshihara
- Mamoru Uemura
- Mutsumi Fukunaga
- Masayoshi Yasui (ORCID: https://orcid.org/0000-0001-6391-3630)
- Yusuke Matsuura (ORCID: https://orcid.org/0000-0002-1469-8329)
- Ken Nakata
- Rei Suzuki (ORCID: https://orcid.org/0000-0002-5093-6726)
- Masakazu Miyake
- Naotsugu Haraguchi (ORCID: https://orcid.org/0000-0002-9826-7170)
- Katsuya Ota
- Akio Fukada
- Kazuya Iwamoto
- Koki Tamai
- Hirofumi Ota
- Atsushi Naito
- Yusuke Takahashi
- Takamichi Komori
- Yuichiro Doki
- Nobuo Takiguchi
- Soichiro Minami
- Mitsuyoshi Tei
- Hirofumi Yamamoto
- Kohei Murata
- Norikatsu Miyoshi
- Taroh Satoh
Institutions
- Tokai University (JP)
- Osaka City University (JP)
- Osaka National Hospital (JP)
- Osaka City General Hospital (JP)
- Osaka International Cancer Institute (JP)
- Saiseikaisenri Hospital (JP)
- Ikeda Municipal Hospital (JP)
- Sakai Municipal Hospital (JP)
- Osaka Rosai Hospital (JP)
- Nara City Hospital (JP)
- Kansai Rosai Hospital (JP)
- Higashi Osaka City General Hospital (JP)
- Osaka Hospital (JP)
- Izumi City General Hospital (JP)
- Hyogo Prefectural Nishinomiya Hospital (JP)
- Otemae Hospital (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- The Oncologist
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1093/oncolo/oyag067
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00