<i>In vitro</i> activity of cefepime/zidebactam against <i>Klebsiella pneumoniae</i> carrying <i>bla</i> KPC variants conferring resistance to ceftazidime/avibactam
Cefepime/zidebactam provided potent <i>in vitro</i> results against KPC-<i>Kp</i> due to <i>bla</i> <sub>KPC</sub> variants, supporting its clinical utility for the treatment of infections due to ceftazidime/avibactam-resistant strains. Also, we demonstrated that zidebactam was not influenced by different <i>bla</i> <sub>KPC</sub> variants.
Authors
- Paolo Gaibani (ORCID: https://orcid.org/0000-0003-3791-8635)
- Carlo Tascini
- Steven Marshall
- Robert A Bonomo
Institutions
- University of Verona (IT)
- University of Udine (IT)
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- Louis Stokes Cleveland VA Medical Center (US)
- Ospedale Santa Maria della Misericordia di Udine (IT)
- University School (US)
- Azienda Sanitaria Universitaria Integrata di Trieste (IT)
- Case Western Reserve University (US)
Publication Details
- Journal
- JAC-Antimicrobial Resistance
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1093/jacamr/dlag026
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00