Central Precocious Puberty and Optic Pathway Glioma in Children with Neurofibromatosis 1: Associations with Tumor Location, Vision, and Treatment
Neurofibromatosis 1-associated optic pathway gliomas (OPGs) may co-occur with central precocious puberty (CPP). Using large language model-based data analysis from 2 NF centers, we compared OPGs in children with NF1, with and without CPP. CPP was associated with hypothalamic involvement, poorer vision, and a higher likelihood of OPG treatment.
Authors
- Carlos E. Prada (ORCID: https://orcid.org/0000-0003-3348-3531)
- Jenny Garzon
- Ethan Hillis
- David H. Gutmann
- Aditi Gupta
- Julia Katz
- Robert Listernick
Institutions
- Northwestern University (US)
- St. Louis Children's Hospital (US)
- Washington University in St. Louis (US)
- Lurie Children's Hospital (US)
- Institute for Medical Informatics and Biostatistics (CH)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Publication Details
- Journal
- The Journal of Pediatrics
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1016/j.jpeds.2026.115055
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 0.00