Metabolic dysfunction-associated steatotic liver disease and bone mineral density in type 2 diabetes mellitus: insights from a single-center cross-sectional study in North India

This study establishes significant, site-specific associations between MASLD and reduced bone mineral density in type 2 diabetes mellitus patients, particularly affecting trabecular-rich skeletal sites. The complex relationship between hepatic steatosis and skeletal health highlights the multisystemic nature of metabolic dysfunction. These findings support integrating bone health assessments and non-invasive hepatic fibrosis screening into routine diabetes care to improve early risk stratification.

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Publication Details

Journal
Frontiers in Endocrinology
Published
2026-03-02
DOI
https://doi.org/10.3389/fendo.2026.1758966
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Metabolic dysfunction-associated steatotic liver disease and bone mineral density in type 2 diabetes mellitus: insights from a single-center cross-sectional study in North India

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Frontiers in Endocrinology
Liver Disease Diagnosis and Treatment
article

Metabolic dysfunction-associated steatotic liver disease and bone mineral density in type 2 diabetes mellitus: insights from a single-center cross-sectional study in North India

Deepak Nathiya, Mahaveer Singh, Anurag Kumar Singh, Neemisha Jain, Sumit Rajotiya, Shivang Mishra, Balvir Singh Tomar, Sourav Debnath, Dogga Sudhakar, Avinash Munshi, Monal Sherekar
article en

Abstract

This study establishes significant, site-specific associations between MASLD and reduced bone mineral density in type 2 diabetes mellitus patients, particularly affecting trabecular-rich skeletal sites. The complex relationship between hepatic steatosis and skeletal health highlights the multisystemic nature of metabolic dysfunction. These findings support integrating bone health assessments and non-invasive hepatic fibrosis screening into routine diabetes care to improve early risk stratification.

Frontiers in EndocrinologyVol. 17
NIMS University (IN), Primary Health Care (QA)
Good health and well-being
Openalex Percentile: Top 38%
Liver Disease Diagnosis and Treatment
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