Assessing PSMA Receptor Availability Using 68Ga-PSMA-11 PET/CT Following 177Lu-PSMA-617 Therapy Administration

There are measurable decreases in PSMA binding following 177Lu-PSMA-617 that resolve over time. As trials consider alternative therapeutic strategies, increasing dosage per cycle alone may not proportionally increase tumor uptake. Our findings warrant validation with a larger number of subjects, standardized post-therapy scan timing, and advanced pharmacokinetic analyses.

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Publication Details

Journal
Clinical Nuclear Medicine
Published
2026-03-02
DOI
https://doi.org/10.1097/rlu.0000000000006302
Primary Topic
Prostate Cancer Treatment and Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Assessing PSMA Receptor Availability Using 68Ga-PSMA-11 PET/CT Following 177Lu-PSMA-617 Therapy Administration

Ka Kit Wong, Molly E Roseland, Yuni K. Dewaraja, Zhonglin Lu et al.
Clinical Nuclear Medicine
Prostate Cancer Treatment and Research
article

Assessing PSMA Receptor Availability Using 68Ga-PSMA-11 PET/CT Following 177Lu-PSMA-617 Therapy Administration

Ka Kit Wong, Molly E Roseland, Yuni K. Dewaraja, Zhonglin Lu, Kellen J. Fitzpatrick, Krithika Suresh, Benjamin L. Viglianti, Kirk A. Frey
article en

Abstract

There are measurable decreases in PSMA binding following 177Lu-PSMA-617 that resolve over time. As trials consider alternative therapeutic strategies, increasing dosage per cycle alone may not proportionally increase tumor uptake. Our findings warrant validation with a larger number of subjects, standardized post-therapy scan timing, and advanced pharmacokinetic analyses.

Clinical Nuclear MedicineVol. 51(4)
University of Michigan (US), Michigan Medicine (US)
Good health and well-being
Openalex Percentile: Top 37%
Prostate Cancer Treatment and Research
DOISourceOpenAlex
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Assessing PSMA Receptor Availability Using 68Ga-PSMA-11 PET/CT Following 177Lu-PSMA-617 Therapy Administration — Ka Kit Wong, Molly E Roseland, et al. · Clinical Nuclear Medicine (2026) | TGRS Research Map | TGRS