Muribaculum intestinale alleviates depressive-like behaviors by inhibiting Th17 cell differentiation and M1 microglia polarization
Loganin exerts antidepressant-like effects by enriching Muribaculum and SCFAs, thereby inhibiting Th17 cell differentiation and M1 microglia polarization. M. intestinale may represent a promising microbial-based therapeutic strategy for depression.
Authors
- Man-ni Wang
- Ying Wang (ORCID: https://orcid.org/0000-0002-1407-2668)
- Weifeng Yin
- Jie‐Kun Xu (ORCID: https://orcid.org/0000-0003-1932-207X)
- Cong‐Yuan Xia
- Wei-Ku Zhang
- jun He
- Guo-Yan Zuo
- Jing-Liang Li
- Xue-Ge Pan
- Hong-Jin Chen
Institutions
- Beijing University of Chinese Medicine (CN)
- China-Japan Friendship Hospital (CN)
- Yale University (US)
Publication Details
- Journal
- Microbiome
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1186/s40168-026-02354-4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00