Acute Hemodynamic Effects of Ivabradine in Pediatric Cardiac Critical Care Patients
Ivabradine seems safe in pediatric patients. It is associated with 3 distinct hemodynamic response phases: the first phase is associated with decreased heart rate and unchanged systemic oxygen delivery, the second phase is associated with increased heart rate and worsened systemic oxygen delivery, and the third phase being associated with decreased heart rate and improved systemic oxygen delivery. These phases coincide with the pharmacokinetic properties of ivabradine.
Authors
- Abdul Wali Khan (ORCID: https://orcid.org/0000-0002-5450-930X)
- Rohit S. Loomba (ORCID: https://orcid.org/0000-0002-9116-2835)
- Alejandro Borquez (ORCID: https://orcid.org/0000-0002-0985-8412)
- Adam K. Morrison (ORCID: https://orcid.org/0000-0002-1050-3416)
- Javier Lasa
- Ashley Yao
- Wesam Sourour
- H Nguyen
- Alyssa Freeman
Institutions
- Northwestern University (US)
- Rady Children's Hospital-San Diego (US)
- Southwestern Medical Center (US)
- Lurie Children's Hospital (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- American Journal of Therapeutics
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1097/mjt.0000000000002113
- Primary Topic
- Heart rate and cardiovascular health
- Type
- article
- Field-Weighted Citation Impact
- 0.00