Molecular characterization of O25:H4 ST131 extraintestinal pathogenic Escherichia coli (ExPEC) harboring a blaOXA-48-carrying IncFII plasmid
This study is the first report of an OXA-48-producing ST131 E. coli C1-M27 strain isolated from a Japanese patient without a history of overseas travel. While the dissemination of bla<sub>OXA-48</sub> is primarily associated with IncL-type plasmids, reports involving IncFII-type plasmids are rare. The high sequence similarity to a European-derived plasmid suggests international transmission of carbapenem resistance plasmids and highlights the potential risk of their further spread.
Authors
- Yuki Wakabayashi (ORCID: https://orcid.org/0000-0001-9786-9121)
- Masaki Anraku (ORCID: https://orcid.org/0009-0009-3720-7906)
- Kaoru Umeda
- Syunya Nishijima
- Hiromi Nakamura
- Ryuji Kawahara
- Yoshimasa Yamamoto
- Satoshi Nakano
- Takahiro Yamaguchi
Institutions
- Gifu University of Medical Science (JP)
- National Institute of Infectious Diseases (JP)
- Osaka Prefectural Institute of Public Health (JP)
- Gifu University (JP)
Publication Details
- Journal
- Journal of Infection and Chemotherapy
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1016/j.jiac.2026.102941
- Primary Topic
- Escherichia coli research studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science