P16 <sup>+</sup> Cells Drive Adverse Postischemic Cardiac Remodeling Through CCL8-Mediated Recruitment of Cytotoxic Lymphocytes
P16<sup>+</sup> cells orchestrate maladaptive remodeling after myocardial infarction through CCL8-dependent recruitment of cytotoxic lymphocytes, particularly CD8<sup>+</sup> T cells, which drive cardiomyocyte apoptosis. Targeting P16<sup>+</sup> fibroblasts or blocking CCL8 offers a promising therapeutic approach for ischemic heart disease.
Authors
- Jufeng Meng (ORCID: https://orcid.org/0000-0002-3035-7225)
- Hui Zhang (ORCID: https://orcid.org/0000-0002-7038-5407)
- Min Ye (ORCID: https://orcid.org/0000-0001-6509-5176)
- Zhengkai Lu (ORCID: https://orcid.org/0009-0009-2166-9970)
- Juan Tang (ORCID: https://orcid.org/0000-0001-9801-4774)
- Lei Yan
- Jialei Zheng
- Anqi Zhu
Institutions
- ShanghaiTech University (CN)
- Shanghai East Hospital (CN)
Publication Details
- Journal
- Circulation
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1161/circulationaha.125.077172
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00