Coexisting genetic kidney disease explains many cases of ‘familial’ IgA nephropathy where the proband has biopsy-confirmed mesangial IgA deposits
Many familial cases of IgA nephropathy result from mesangial IgA deposition in the setting of coexisting genetic kidney disease. Sometimes, genetic kidney disease is not detected in the proband but is present in another family member. Individuals from families with IgA nephropathy should be offered genetic testing.
Authors
- Y. N. Li
- David Barit
- Robert G. Fassett (ORCID: https://orcid.org/0000-0002-5318-6940)
- Russell B. Auwardt
- Mary Huang
- Timothy J. Pianta (ORCID: https://orcid.org/0000-0002-9196-4889)
- Kathy Paizis (ORCID: https://orcid.org/0000-0002-3580-1970)
- Francesco L. Ierino (ORCID: https://orcid.org/0000-0002-8189-4952)
- Khalid Mahmood
- Deb Colville
- David Langsford
- Jing Zhang
- Ziming Zhou
- Bocheng Huang
- Zhuo Jun Yin
- Judy Savige
Institutions
- The University of Melbourne (AU)
- Northern Health (AU)
- North West Regional Hospital (AU)
- Melbourne Bioinformatics (AU)
- The Royal Victorian Eye & Ear Hospital (AU)
- Albury Wodonga Health (AU)
- Austin Health (AU)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-03-02
- DOI
- https://doi.org/10.3389/fmed.2025.1647695
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00