Association of circadian rhythms, MTNR1B, BMAL1, BMAL2, and CRY2 gene polymorphisms and their interactions with type 2 diabetes in coal miners
The interaction between circadian rhythm disruption and high-risk SNP genotypes further amplifies the risk of T2DM among coal miners. Notably, the five-factor interaction model (rs10830963-rs7950226-rs7958822-rs11605924-CICRD) provides a standardized basis for assessing circadian rhythm disruption, screening high-risk populations, and identifying that high-risk genetic combinations are unsuitable for shift work, offering scientific evidence for the precision prevention of T2DM in coal miners.
Authors
- Juxiang Yuan
- Qing Li (ORCID: https://orcid.org/0000-0002-3529-8156)
- Haoyue Cao
- Chunze Zhang
Institutions
- North China University of Science and Technology (CN)
- Tianjin First Center Hospital (CN)
- Heilongjiang Center for Tuberculosis Control and Prevention (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.3389/fendo.2026.1567465
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00