MiR-19b-3p facilitates colorectal cancer metastasis by mediating the crosstalk between tumor-associated endothelial cells and malignant cells
Our findings reveal that miR-19b-3p orchestrates tumor-endothelial interactions by synchronously promoting EMT and EndMT, thereby driving a pro-metastatic microenvironment. Circulating miR-19b-3p represents a promising biomarker and potential therapeutic target in metastatic colorectal cancer.
Authors
- Yixin Cao (ORCID: https://orcid.org/0000-0002-5227-8587)
- Xuequan Wang (ORCID: https://orcid.org/0000-0002-8251-7622)
- Zhongyi Hua
- Qin Zhang (ORCID: https://orcid.org/0000-0003-4161-1871)
- Yongwang Xue
- Xinyu Kai
- Runting Yin
- Xiangyang Wang
- Yuan Wei
- Jia Zhang
Institutions
- Jiangsu University (CN)
- Xinjiang Medical University (CN)
- Wenzhou Medical University (CN)
- Nanjing Traditional Chinese Medicine Hospital (CN)
- Affiliated Hospital of Jiangsu University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.3389/fonc.2026.1701701
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00