Network toxicology and single-cell analysis reveal key gene-mediated bisphenol a interference with granulosa cell function in polycystic ovary syndrome
BPA exposure disrupts granulosa cell survival in PCOS by driving apoptosis-related molecular reprogramming through key gene regulation, thereby elucidating mechanistic links between environmental pollutants and PCOS progression and highlighting potential molecular targets for intervention.
Authors
- Hanjun Huang (ORCID: https://orcid.org/0000-0002-1808-7189)
- Xia Liu (ORCID: https://orcid.org/0000-0002-9209-0562)
- Xiumei Xiong (ORCID: https://orcid.org/0009-0006-9220-516X)
- Xiujuan Chen
- Yuan Lin
- Yan Zhang
Institutions
- Fujian Medical University (CN)
- Fuzhou Maternity and Child Health Care Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.3389/fphar.2026.1754568
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 0.00