Real-world outcomes of third-line systemic therapy after immune checkpoint inhibitor combinations and subsequent VEGFR-TKIs in advanced renal cell carcinoma

Third-line systemic therapy following ICI combinations and sequential VEGFR-TKIs shows feasible clinical effectiveness and manageable toxicity in real-world patients with advanced RCC.

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Publication Details

Journal
Japanese Journal of Clinical Oncology
Published
2026-02-17
DOI
https://doi.org/10.1093/jjco/hyag037
Primary Topic
Renal cell carcinoma treatment
Type
article
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article

Real-world outcomes of third-line systemic therapy after immune checkpoint inhibitor combinations and subsequent VEGFR-TKIs in advanced renal cell carcinoma

T. Takagi, Hiroaki Shimmura, Shinsuke Mizoguchi, Kazuhiko Yoshida et al.
Japanese Journal of Clinical Oncology
Renal cell carcinoma treatment
article

Real-world outcomes of third-line systemic therapy after immune checkpoint inhibitor combinations and subsequent VEGFR-TKIs in advanced renal cell carcinoma

T. Takagi, Hiroaki Shimmura, Shinsuke Mizoguchi, Kazuhiko Yoshida, Yasunobu Hashimoto, Koichi Nishimura, Hironori Fukuda, Junpei Iizuka, Yuki Nemoto, Takayuki Nakayama, Tsunenori Kondo, Hiroki Ishihara
article en

Abstract

Third-line systemic therapy following ICI combinations and sequential VEGFR-TKIs shows feasible clinical effectiveness and manageable toxicity in real-world patients with advanced RCC.

Japanese Journal of Clinical Oncology
Kawaguchi Junior College (JP), Jyoban Hospital of Tokiwa Foundation (JP), Tokyo Women's Medical University Adachi Medical Center (JP), Tokyo Women's Medical University (JP), Noguchi Hospital (JP), Saiseikai Ibaraki Hospital (JP)
Good health and well-being
Openalex Percentile: Top 37%
Renal cell carcinoma treatment
DOISourceOpenAlex
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