Sintilimab-induced toxic epidermal necrolysis complicated in advanced gastric cancer: a case report and literature review
Although effective for gastric cancer, sintilimab may rarely induce life-threatening TEN. Early recognition, immediate ICI withdrawal, and coordinated multidisciplinary care are pivotal to survival. This case highlights the importance of early recognition, immediate discontinuation of ICIs, and coordinated multidisciplinary management in patients who develop life-threatening cutaneous immune-related adverse events.
Authors
- Qi Zhao (ORCID: https://orcid.org/0000-0002-8683-6145)
- Yandong Miao (ORCID: https://orcid.org/0000-0002-1429-8915)
- Li-Na Wang
- Rui-Bin Wang
- Hai-Peng Zou
- Wei Zhang
- Ling-Xia Yu
- Rui-Ke Cao
Institutions
- Academy of Medical Sciences (GB)
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Xinhui People's Hospital (CN)
- Southern Medical University (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.3389/fimmu.2026.1771194
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Binzhou Medical University