Uncovering the immune-related PCD genes in chronic rhinosinusitis with nasal polyps inflammatory progression: a machine learning and functional validation study

<i>CD209, CYBB, FPR1, IL2RB</i> and <i>TYROBP</i> were valuable immune-related PCD signature genes for clinical prognosis of CRSwNP. In addition, macrophages may play a key role in the chronic inflammation process of CRSwNP via activating immune-associated pathways. These findings may provide compelling evidence for early diagnosis and personalized therapeutic approaches in CRSwNP management.