Sohlh2 inhibited the angiogenesis of hepatocellular carcinoma through the HIF-1α/VEGFA pathway

Our research suggested that that Sohlh2 exerted a tumor-suppressing gene function in hepatocellular carcinoma by inhibiting the HIF-1α/VEGFA signaling pathway. These findings provided a potential molecular target for the development of anti-angiogenic therapies in HCC.

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Publication Details

Journal
Translational Oncology
Published
2026-03-02
DOI
https://doi.org/10.1016/j.tranon.2026.102718
Primary Topic
Cancer, Hypoxia, and Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

Sohlh2 inhibited the angiogenesis of hepatocellular carcinoma through the HIF-1α/VEGFA pathway

Sen Chen, Yanfang Wu, Jing Wang, Qing Liu
Translational Oncology
Cancer, Hypoxia, and Metabolism
article

Sohlh2 inhibited the angiogenesis of hepatocellular carcinoma through the HIF-1α/VEGFA pathway

Sen Chen, Yanfang Wu, Jing Wang, Qing Liu
article en

Abstract

Our research suggested that that Sohlh2 exerted a tumor-suppressing gene function in hepatocellular carcinoma by inhibiting the HIF-1α/VEGFA signaling pathway. These findings provided a potential molecular target for the development of anti-angiogenic therapies in HCC.

Translational OncologyVol. 66
Yantaishan Hospital (CN)
Openalex Percentile: Top 37%
Cancer, Hypoxia, and Metabolism
DOIOpen Access PDFOpenAlex
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Sohlh2 inhibited the angiogenesis of hepatocellular carcinoma through the HIF-1α/VEGFA pathway — Sen Chen, Yanfang Wu, et al. · Translational Oncology (2026) | TGRS Research Map | TGRS