Effects of early vs. late administration of labetalol on maternal cerebral perfusion and fetal growth in severe pre-eclampsia

Early initiation of intravenous labetalol was associated with improved maternal cerebral perfusion and more rapid blood pressure stabilization, without an increase in adverse maternal or neonatal outcomes. These findings highlight the importance of timely antihypertensive therapy in severe pre-eclampsia, although prospective studies are required to establish causality and long-term clinical benefit.