Synonymous ADHFE1 Variation Shapes Population Tolerability of the Deleterious ALDH2 rs671 Allele

This study identifies population-specific common and rare genetic variants by analyzing allele frequency differences across populations using gnomAD v2.1.1 exome sequencing data. We developed a customized filtering pipeline that performs rigorous quality control and stratified analysis across seven genetic ancestries: East Asian (EAS), South Asian (SAS), Non-Finnish European (NFE), Finnish (FIN), African (AFR), Admixed American (AMR), and Ashkenazi Jewish (ASJ).