Knowledge-based planning for intensity-modulated proton therapy of the breast and chest wall with regional lymph nodes: development, validation, and comparative evaluation of two models
KBP models can generate clinically acceptable IMPT plans for breast and CW with regional lymph nodes, achieving comparable target coverage to clinical plans with modest improvements in OAR sparing and hot spot reduction, supporting their potential to streamline treatment planning.
Authors
- Elizabeth L. Bossart (ORCID: https://orcid.org/0000-0003-1547-0868)
- Robert Kaderka
- Hayden Guerrero
- Cristiane Takita (ORCID: https://orcid.org/0009-0006-4956-4415)
- Jonathan Cyriac
- Yihang Xu (ORCID: https://orcid.org/0000-0002-3757-728X)
- Nesrin Dogan
- Parker Anderson
Institutions
- University of Miami (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.3389/fonc.2026.1717884
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Varian Medical Systems