Interstitial cells and arrhythmia
The electrophysiological relevance of interstitial nonmyocytes for cardiac electrophysiology arises from their abundant direct and indirect interactions with cardiac myocytes. This review defines the interstitium, explores biophysical and biochemical mechanisms of interactions between interstitial components and cardiac myocytes, illustrates consequences of these interactions for heart rhythm, and identifies targets for further research in this area.
Authors
- Thorsten Kessler (ORCID: https://orcid.org/0000-0003-3326-1621)
- Jana Grune (ORCID: https://orcid.org/0000-0001-6209-7416)
- Peter Karl Kohl (ORCID: https://orcid.org/0000-0003-0416-6270)
- Eva A. Rog‐Zielinska (ORCID: https://orcid.org/0000-0002-3295-4728)
- Achim Lother
Institutions
- University of Freiburg (DE)
- University Medical Center (US)
- Deutsches Herzzentrum München (DE)
- Berlin Heart (Germany) (DE)
- Saarland University (DE)
Publication Details
- Journal
- American Journal of Physiology-Cell Physiology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1152/ajpcell.00882.2025
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00