Serial blood serum measurements of calprotectin and deoxyribonuclease in COVID-19 patients during hospitalization and recovery until one year: a prospective, multicenter, observational study
COVID‑19 non‑survivors showed persistently higher calprotectin levels during prolonged hospitalization, and elevated admission calprotectin was associated with later pandemic waves and poorer oxygenation. Incorporating calprotectin with ferritin improved prediction of ICU/HDU admission. DNase levels were lower at admission in non‑survivors, while overall DNase remained elevated from hospitalization through 1‑year follow‑up compared with HC, suggesting a possible role in long‑term COVID‑19-related immune alterations.
Authors
- Thor Ueland (ORCID: https://orcid.org/0000-0001-5005-0784)
- Simen Bøe
- Anders Aune Tveita (ORCID: https://orcid.org/0000-0002-0668-9262)
- Beathe Kiland Granerud (ORCID: https://orcid.org/0000-0002-6951-2317)
- Mohammad Reza Mirlashari (ORCID: https://orcid.org/0000-0003-0562-0025)
- Geir Hetland
- Jan Cato Holter
- Lars Heggelund
- Lise Sofie Nissen-Meyer
- on behalf of Norwegian SARS-CoV-2 study group
- Anne Ma Dyrhol-Riise
- Anders Benjamin Kildal
- Aleksander Rygh Holten
- Magne Kristoffer Fagerhol
- Karl Erik Müller
Institutions
- Oslo University Hospital (NO)
- University Hospital of North Norway (NO)
- University of Oslo (NO)
- Drammen Hospital (NO)
- Vestre Viken Hospital Trust (NO)
- Hammerfest Hospital (NO)
- Thrombosis Research Institute (GB)
- University of Bergen (NO)
- UiT The Arctic University of Norway (NO)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1186/s12879-026-12939-x
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00