SPATIALLY PATTERNED PODOCYTE STATE TRANSITIONS COORDINATE AGING OF THE GLOMERULUS
The single nuclei transcriptomics of the aging kidney provides a mechanistic explanation for regional susceptibility of nephrons and suggests that the future therapeutic strategies need to consider the cellular and spatial complexity of the glomerulus.
Authors
- Christopher Chaney (ORCID: https://orcid.org/0000-0002-4144-4180)
- Stuart J. Shankland (ORCID: https://orcid.org/0000-0002-4616-8330)
- Diana Y. Eng
- Jeffrey W. Pippin (ORCID: https://orcid.org/0009-0000-1629-1728)
- Oliver Wessely (ORCID: https://orcid.org/0000-0001-6440-7975)
- Uyen Tran
- Juliang Wang
Institutions
- Cleveland Clinic (US)
- University of Washington (US)
- Cleveland Clinic Lerner College of Medicine (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-03-02
- DOI
- https://doi.org/10.64898/2026.02.27.708213
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00