Day + 30 detection of minimal residual FLT3-ITD by high-sensitivity PCR-NGS predicts relapse risk and guides post-transplant maintenance in AML
This is the first study to demonstrate that detection of minimal FLT3-ITD clones at the fixed time point of day + 30 post-HSCT can reliably stratify relapse risk in AML patients and provide a rationale for individualized post-transplant maintenance therapy.
Authors
- S. feng
- Jiaxin Cao (ORCID: https://orcid.org/0009-0006-7273-0581)
- J J Wei
- Yigeng Cao
- Pan Pan (ORCID: https://orcid.org/0000-0002-9573-9443)
- Dan Feng (ORCID: https://orcid.org/0009-0001-6300-9980)
- Weihua Zhai
- Mingzhe Han
- Qiaoling Ma
- Yawei Zheng
- Nan Yang
- Yao Yao
- Aiming Pang
- Xin Chen
- Chen Liang
- Wenbin Cao
- Shan Jiang
- Donglin Yang
- Yi He
- Li Wan
- Rongli Zhang
- Jiao Ma
- Erlie Jiang
Institutions
- Tianjin University of Technology (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Tianjin Anding Hospital (CN)
- Institute of Hematology & Blood Diseases Hospital (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1186/s12916-026-04744-9
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00