OCTOPOS.jl – A user-friendly tool for synonymous genetic code optimization
The genetic code of organisms connects which codons will be translated to which aminoacid. There are multiple codons which encode the same aminoacid, but they have differing translation dynamics. This can be used to alter the translation dynamic of a mRNA without changing the resulting protein. OCTOPOS.jl is a Julia package for optimizing mRNA sequences by synonomous exchange of codons. This can be used for example to increase protein yield in different host organisms.A web interface is available at https://octopos.cell.uni-hannover.de.
Authors
- Simon Christ (ORCID: https://orcid.org/0000-0002-5866-1472)
- Sophia Rudorf (ORCID: https://orcid.org/0000-0001-7653-3733)
- Jan-Hendrik Trösemeier
- Christel Kamp
Institutions
- Leibniz University Hannover (DE)
- Deutsche Bahn (Germany) (DE)
- Paul Ehrlich Institut (DE)
Publication Details
- Journal
- Zenodo (CERN European Organization for Nuclear Research)
- Published
- 2024-10-23
- DOI
- https://doi.org/10.5281/zenodo.18834589
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00