CSF Proteomic Profiles Associated With White Matter Integrity in Cognitively Normal Older Adults With and Without Amyloid Pathology

Loss of WM integrity in the very early stages of AD seems to be related to alterations in biological processes associated with neuronal plasticity and oligodendrocyte integrity. Our findings provide new insights into the distinct biological mechanisms regulating WM integrity and its relationship with AD pathology.

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Publication Details

Journal
Neurology
Published
2026-03-02
DOI
https://doi.org/10.1212/wnl.0000000000214675
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

CSF Proteomic Profiles Associated With White Matter Integrity in Cognitively Normal Older Adults With and Without Amyloid Pathology

Flora H. Duits, Mario Tranfa, Senne B. Lageman, Lisa Vermunt et al.
Neurology
Dementia and Cognitive Impairment Research
article

CSF Proteomic Profiles Associated With White Matter Integrity in Cognitively Normal Older Adults With and Without Amyloid Pathology

Flora H. Duits, Mario Tranfa, Senne B. Lageman, Lisa Vermunt, Mara ten Kate, M. Pardini, S. Garbarino, Luca Roccatagliata, Diederick de Leeuw, Charlotte E. Teunissen, Frederik Barkhof, Pieter Jelle Visser, Wiesje M. Van Der Flier, Betty M. Tijms, Anouk den Braber
article en

Abstract

Loss of WM integrity in the very early stages of AD seems to be related to alterations in biological processes associated with neuronal plasticity and oligodendrocyte integrity. Our findings provide new insights into the distinct biological mechanisms regulating WM integrity and its relationship with AD pathology.

NeurologyVol. 106(7)
Netherlands Institute for Neuroscience (NL), Maastricht University (NL), Amsterdam Neuroscience (NL), Ospedale Policlinico San Martino (IT), University College London (GB), University of Naples Federico II (IT), University of Genoa (IT), Vrije Universiteit Amsterdam (NL)
Openalex Percentile: Top 44%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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CSF Proteomic Profiles Associated With White Matter Integrity in Cognitively Normal Older Adults With and Without Amyloid Pathology — Flora H. Duits, Mario Tranfa, et al. · Neurology (2026) | TGRS Research Map | TGRS