N-Heterocyclic Carbene-Catalyzed E1cB Elimination: A Strategy for Synthesizing Heteroaryl- <i>C</i> -Δ ^1,2 -Glycosides

This work reports an unprecedented and efficient approach for the synthesis of a diverse range of heteroaryl-<i>C</i>-Δ^1,2-glycosides via N-heterocyclic carbene (NHC)-catalyzed E1cB elimination. The method provides a highly practical, scalable, and broadly applicable strategy, delivering excellent yields across various substrates. Importantly, under the optimized conditions, numerous sensitive functional and protecting groups in the heteroaryl-<i>C</i>-Δ^1,2-glycosides remained intact.