Injectable dual-drug hydrogel containing curcumin and glycyrrhizic acid for biofilm inhibition and immunomodulatory therapy in periodontitis
This study presents an injectable dual-drug hydrogel, CURM@GLH, that integrates biofilm inhibition with immunomodulatory regulation, offering a promising host-directed therapeutic strategy for periodontitis. The proposed approach provides new insights into the design of multifunctional biomaterials for the treatment of chronic inflammatory diseases associated with biofilm persistence and immune imbalance.
Authors
- Meilin Hu (ORCID: https://orcid.org/0000-0001-8920-6934)
- Chenyu Xu (ORCID: https://orcid.org/0009-0005-6360-6741)
- Hanqi Li
- Xiaoyu Chen (ORCID: https://orcid.org/0000-0003-0426-8920)
- Dayong Liu
- Tengye Lian
- Lu Sun
- Yubo Hu
- Shiduo Sun
Institutions
- Hebei Medical University (CN)
- Aurora Periodontics and Implant Dentistry (US)
- Stomatological Hospital of Chongqing Medical University (CN)
- Chongqing Municipal Government (CN)
- Tianjin Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1186/s12951-026-04219-2
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00