High-throughput screened kaempferitrin potentiates trastuzumab efficacy in HER2-positive gastric cancer by targeting Cyclooxygenase-2 to inhibit ERK signaling
Our study shows that kaempferitrin as a promising sensitizer of trastuzumab, which enhances its therapeutic efficacy against HER-positive GC progression by suppressing COX2/ERK signaling.
Authors
- Qichen He (ORCID: https://orcid.org/0009-0006-3187-7130)
- Chong Li (ORCID: https://orcid.org/0000-0003-4340-7436)
- Wengui Shi
- Zuoyi Jiao
- Jumei Yang
- Hongwei Yu
- Lele Wu
- Feifei Pan
Institutions
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1016/j.phymed.2026.158034
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00