Lamins’ role in osteosarcoma

Osteosarcoma (OS) is a rare and highly aggressive bone tumor that can develop in several skeletal segments, although it predominantly affects the long bones. This cancer mostly occurs in adolescents, young adults and people older than 60. There are many questions still open regarding osteosarcoma biology and the efficacy of current treatments. Recent research has increasingly emphasized the critical role of mechanotransduction as a key regulator of cellular functions. Notably, emerging evidence highlights the nucleus as an active player in mechanosensing and mechanotransduction processes within the bone tissue. The nuclear envelope is composed of several proteins, among which lamins. These proteins are essential components of the inner nuclear membrane (INM) exerting many different functions, also known for having a pivotal role in mechanotransduction and bone cell differentiation. In this review, we analyze the state of the art regarding the lamins role in bone cancer biology.