Piezo2 mechanically regulate scleral fibroblast differentiation by activating relA/RhoA pathway
Piezo2 acts as a mechanotransduction ion channel in myopia sclera, by modulating Ca<sup>2+</sup>-dependent relA/RhoA pathway. This mechanoresponsive signaling is essential for fibroblast to myofibroblast differentiation.
Authors
- Qingping Yao (ORCID: https://orcid.org/0000-0002-6539-5803)
- Ying Yuan (ORCID: https://orcid.org/0000-0003-2440-4053)
- Bilian Ke
- Mengxiao Li
- Yingxin Qi
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai Eye Disease Prevention & Treatment Center (CN)
Publication Details
- Journal
- Experimental Eye Research
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1016/j.exer.2026.110955
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00