IL-6 Receptor Antagonists and Severe Post-COVID-19 Outcomes: An Emulated Target Trial

IL-6 receptor antagonists may prevent the incidence of severe post-COVID-19 outcomes, such as Long COVID or mortality. This supports the hypothesis that IL-6 may be a mechanistic biomarker of COVID-19 sequelae and that acute COVID-19 severity may mediate this relationship.

Authors

M Narendra Kumar
Yunwen Ji (ORCID: https://orcid.org/0000-0002-6077-5102)
Rachel Wong (ORCID: https://orcid.org/0000-0001-7837-2881)
Letianchu Wang
Eric Hurwitz (ORCID: https://orcid.org/0000-0002-6581-7754)
Rena C Patel
Carolyn Bramante
Zachary Butzin-Dozier
A. Jerrod Anzalone
Benjamin Sines

Institutions

University of North Carolina at Chapel Hill (US)
University of Minnesota (US)
University of Alabama at Birmingham (US)
Stony Brook School (US)
Berkeley Public Health Division (US)
University of Nebraska Medical Center (US)
Stony Brook University (US)
University of California, Berkeley (US)

Publication Details

Journal: medRxiv
Published: 2026-03-02
DOI: https://doi.org/10.64898/2026.02.27.26347274
Primary Topic: Long-Term Effects of COVID-19
Type: article
Field-Weighted Citation Impact: 0.00

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article

IL-6 Receptor Antagonists and Severe Post-COVID-19 Outcomes: An Emulated Target Trial

M Narendra Kumar, Yunwen Ji, Rachel Wong, Letianchu Wang et al.

Mar 2, 2026

medRxiv

Long-Term Effects of COVID-19

article

IL-6 Receptor Antagonists and Severe Post-COVID-19 Outcomes: An Emulated Target Trial

M Narendra Kumar, Yunwen Ji, Rachel Wong, Letianchu Wang, Eric Hurwitz, Rena C Patel, Carolyn Bramante, Zachary Butzin-Dozier, A. Jerrod Anzalone, Benjamin Sines

March 2, 2026article en

Abstract

IL-6 receptor antagonists may prevent the incidence of severe post-COVID-19 outcomes, such as Long COVID or mortality. This supports the hypothesis that IL-6 may be a mechanistic biomarker of COVID-19 sequelae and that acute COVID-19 severity may mediate this relationship.

medRxiv

University of North Carolina at Chapel Hill (US), University of Minnesota (US), University of Alabama at Birmingham (US), Stony Brook School (US), Berkeley Public Health Division (US), University of Nebraska Medical Center (US), Stony Brook University (US), University of California, Berkeley (US)

Good health and well-being

Openalex Percentile: Top 43%

Long-Term Effects of COVID-19

DOI Open Access PDF OpenAlex

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IL-6 Receptor Antagonists and Severe Post-COVID-19 Outcomes: An Emulated Target Trial — M Narendra Kumar, Yunwen Ji, et al. · medRxiv (2026) | TGRS Research Map | TGRS