Dual-omics analysis of key biomarkers in T cell ubiquitination of rheumatoid arthritis blood and synovial tissue, validated by two-sample Mendelian randomization and qPCR
Integrative dual-omics and MR analyses identified key ubiquitination-related T-cell genes driving RA pathogenesis. <i>NOP58</i> and <i>GCC2</i> represent potential causal biomarkers and therapeutic targets, offering novel insights into immune regulation and precision intervention in RA.
Authors
- Jinghong Meng
- Danting He
- Haitao Zhao
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.3389/fimmu.2026.1764990
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00