Coq4 deficiency induces placental vascular development defects through FSP1/CoQ10 axis-mediated endothelial ferroptosis
This study demonstrates that Coq4 deficiency induces endothelial ferroptosis via disrupting the FSP1-CoQ10 antioxidant axis, and may also provide new insights into the pathogenesis of pregnancy complications caused by placental dysfunction and iron-related vascular diseases, while offering novel approaches for exploring potential therapeutic targets.
Authors
- Xueke He
- Chen Ra
- Miao Jiang (ORCID: https://orcid.org/0000-0002-4929-4885)
- Sikun Wang
Institutions
- Army Medical University (CN)
- Southwest Hospital (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.3389/fcell.2026.1774201
- Primary Topic
- Coenzyme Q10 studies and effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province