Pilot study of screening method for pancreatic cancer using lipidomic profiling of plasma or serum
This pilot study demonstrates the promising potential of lipidomic profiling as a noninvasive, blood-based screening tool for pancreatic cancer. The method outperforms current biomarkers, maintains high diagnostic accuracy in early-stage disease, and performs reliably in high-risk populations. These findings support the initiation of a clinical trial aimed at validating the lipidomic test for the early detection of PDAC.
Authors
- Robert Jirásko (ORCID: https://orcid.org/0000-0001-5795-5017)
- Ondřej Peterka (ORCID: https://orcid.org/0000-0002-9358-9138)
- M. Loveček
- Karolína Pešková (ORCID: https://orcid.org/0000-0002-0193-1478)
- Jan Trna (ORCID: https://orcid.org/0000-0003-3138-9736)
- Jakub Idkowiak (ORCID: https://orcid.org/0000-0002-4336-9006)
- Milan Vošmik (ORCID: https://orcid.org/0000-0001-6497-7505)
- O. Urban
- Zuzana Dolečková
- Beatrice Mohelníková-Duchoňová
- Irena Kozubíková
- Petr Karásek
- Ondřej Slavíček
- Mária Dosoudilová
- Michal Holčapek
- Bohuslav Melichar
- Josef Bártl
Institutions
- University of Pardubice (CZ)
- Charles University (CZ)
- VIB-KU Leuven Center for Cancer Biology (BE)
- University Hospital Olomouc (CZ)
- Masaryk Memorial Cancer Institute (CZ)
- University Hospital Hradec Králové (CZ)
- General University Hospital in Prague (CZ)
- Palacký University Olomouc (CZ)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-03-02
- DOI
- https://doi.org/10.1038/s43856-026-01445-5
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Univerzita Palackého v Olomouci
- Agentura Pro Zdravotnický Výzkum České Republiky