A Phase 1 Study of Neoadjuvant Cabozantinib in Combination With Radiation Therapy for Sarcomas of the Extremities

In this phase 1 trial, concurrent cabozantinib/RT was feasible and demonstrated an acceptable safety profile for patients with extremity STS.

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Publication Details

Journal
American Journal of Clinical Oncology
Published
2026-02-23
DOI
https://doi.org/10.1097/coc.0000000000001311
Primary Topic
Sarcoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

A Phase 1 Study of Neoadjuvant Cabozantinib in Combination With Radiation Therapy for Sarcomas of the Extremities

Rylee Johnson, Stephanie K. Schaub, Michael J. Wagner, Munther Baroudi et al.
American Journal of Clinical Oncology
Sarcoma Diagnosis and Treatment
article

A Phase 1 Study of Neoadjuvant Cabozantinib in Combination With Radiation Therapy for Sarcomas of the Extremities

Rylee Johnson, Stephanie K. Schaub, Michael J. Wagner, Munther Baroudi, Elyse J. Brinkmann, Elizabeth T. Loggers, Edward Kim, Lee Cranmer, Roxanne Moore, Jesse L. Roberts, Niall Morin, Ted Gooley, Matthew Thompson, Hannah R. Abrams
article en

Abstract

In this phase 1 trial, concurrent cabozantinib/RT was feasible and demonstrated an acceptable safety profile for patients with extremity STS.

American Journal of Clinical Oncology
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA), University of Washington (US), City of Hope (US), Dana-Farber Cancer Institute (US), Clinical Research Management (US)
Good health and well-being
Openalex Percentile: Top 38%
Sarcoma Diagnosis and Treatment
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A Phase 1 Study of Neoadjuvant Cabozantinib in Combination With Radiation Therapy for Sarcomas of the Extremities — Rylee Johnson, Stephanie K. Schaub, et al. · American Journal of Clinical Oncology (2026) | TGRS Research Map | TGRS