Sexual dimorphism in keratoconus: transcriptomic and hormonal mechanisms underlying stromal remodelling
KC exhibited sex-biased molecular programs consistent with androgen-driven and oestrogen-deficiency-related stromal remodelling. These findings elucidate hormone-driven mechanisms underlying KC and suggest that sex-associated hormonal regulation could inform future personalised therapeutic strategies.
Authors
- ShiHao Chen
- Xintong Yu (ORCID: https://orcid.org/0000-0002-4916-671X)
- Binjia Sun
- Yining Sun
- Kaisheng Wang (ORCID: https://orcid.org/0000-0001-5039-2098)
- Ruoqi Wang
- Wei Chen
- Dan Jiang
- Qixin Li
- Ye Yu
- Xiaoqing Wu
Institutions
- Wenzhou Medical University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
Publication Details
- Journal
- Eye and Vision
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1186/s40662-026-00478-0
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China