Integrative study reveals <i>NR1D1</i> mediates <i>Hedyotis diffusa</i> ’s antifibrosis <i>via</i> hypoxia inducible factor-1/ammonia axis
HD demonstrates unequivocal efficacy in combating HF, potentially by modulating HIF-1 and the urea cycle through its influence on circadian rhythm genes, with <i>NR1D1</i> as a prominent representative target.
Authors
- Siwei Xia
- Kai-Yao Yang
- Jingwen Zhou (ORCID: https://orcid.org/0000-0003-1786-2574)
- Li Chen
- Huan Liu
- Yi-Jie Gao
- De-Song Kong
- Hong-Yan Wu
- Feng Zhang
- Meng-Ru Zhang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangsu Vocational College of Medicine (CN)
- Yancheng Vocational Institute of Industry Technology (CN)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2026-03-02
- DOI
- https://doi.org/10.3748/wjg.v32.i10.115334
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00