CYP2C19 genetic polymorphisms and proton pump inhibitor therapy resistance in patients with gastrooesophageal reflux disease: a preliminary observational cohort study
Findings from this preliminary study indicate a higher frequency of NMs and RMs compared to IMs and PMs in this PPI-resistant cohort with GORD. Most resistance was observed to the second-generation PPI esomeprazole. A limitation was the lack of a control group comprising PPI-sensitive patients.
Authors
- Francesca Wirth (ORCID: https://orcid.org/0000-0002-3225-2363)
- Graziella Zahra
- Lilian M. Azzopardi (ORCID: https://orcid.org/0000-0002-3811-0761)
- C Barbara
- Jamie-Lee DeBattista
- John Schembri
Institutions
- University of Malta (MT)
- Mater Dei Hospital (MT)
Publication Details
- Journal
- Drug Metabolism and Personalized Therapy
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1515/dmpt-2025-0077
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00