Special Issue: The Evolving Landscape of Single-Cell Genomics in CNS and PNS Oncology

Single-cell genomics has transformed neuro-oncology, revealing the cellular and molecular diversity of tumors across the central and peripheral nervous systems (CNS and PNS). [1][2]][3][4][5] These approaches have highlighted intratumoral heterogeneity, identified the molecular programs driving malignancy and refined our understanding of the tumor microenvironment. 2 In recent years, this technology has been increasingly applied to tumors of the CNS and PNS, revealing complexities that bulk genomic method cannot capture.This special issue of Neuro-Oncology Advances explores the transformative impact of single-cell technologies on the characterization of CNS and PNS tumors.It provides a comprehensive overview of current advancements, showcasing how single-cell genomics is reshaping our understanding of brain, spine, and peripheral nerve tumors.The goal of this special issue is to consolidate existing knowledge, foster collaborations, and guide future research that integrates single-cell analyses into neuro-oncology.Below is a summary of the articles included in this special issue, organized by category and highlighting their significance.