METTL16 Modulates GPX4 Expression to Regulate Chondrocyte Ferroptosis
Overexpression of <i>METTL16</i> improved bone growth and alleviated ferroptosis of chondrocytes by increasing m<sup>6</sup>A modification of GPX4 mRNA and thus GPX4 expression in chondrocytes. The METTL16/GPX4 axis may be a promising therapeutic approach for ACH treatment.
Authors
- He Li (ORCID: https://orcid.org/0000-0002-7243-6474)
- Xiaoming Wang (ORCID: https://orcid.org/0009-0002-6740-4977)
- Xiaowei Wang
- Bing Wang
- Xing Tong
- Ming Yang
Institutions
- Xi'an Honghui Hospital (CN)
- Xi’an Children’s Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2026-02-03
- DOI
- https://doi.org/10.31083/fbl45159
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00