Vitamin D Status in Patients with Primary Hyperparathyroidism: Results from a Retrospective Study

Abstract Introduction: Primary Hyperparathyroidism (PHPT) is frequently associated with vitamin D deficiency, which may exacerbate hyperparathyroidism, hypercalcemia, and bone complications. Objective: To assess vitamin D status in patients with PHPT and analyze its biological and clinical impact. Patients and Methods: A retrospective study conducted over seven years (2015-2022) including patients hospitalized for PHPT. Serum 25-hydroxyvitamin D [25(OH)D] levels were systematically measured. Results: Sixty-three patients were included (mean age: 55.8 years). The mean 25(OH)D level was 19.2 ng/mL. Vitamin D deficiency was observed in 60.3% of patients, insufficiency in 17.5%, and normal status in 22.2%. Patients with vitamin D deficiency had significantly higher serum calcium and Parathyroid Hormone (PTH) levels. Conclusion: Vitamin D deficiency is highly prevalent among patients with PHPT and is associated with a more severe biological profile. Routine screening and correction of vitamin D deficiency should be integral to patient management.