Aerobic Running Training Attenuates Lipid and Protein Oxidation and Modulates Membrane Dynamics in Metabolically Active Tissues

Chronic aerobic treadmill training induces protective adaptations against oxidative stress in skeletal muscle, heart, and brain. The reduction in lipid peroxidation and protein oxidation, along with changes in membrane fluidity, reflects enhanced cellular resilience and structural integrity. These results support the role of sustained aerobic exercise as a non-pharmacological strategy to mitigate oxidative damage and promote tissue health. The rat model used provides translational relevance for understanding exercise-induced protection mechanisms.